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In a 2018 double-blind trial of 100 depressed patients, 1,000 mcg/day adjunct therapy lifted mood scores by 35% after 3 months, outperforming antidepressants alone

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"We know that's a lot of inappropriate care that happens in Canada," said study co-author Dr

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StatPearls (US source) states, Patients generally receive lifelong intramuscular (IM) injections of vitamin B12 (typically 1000 g per month)