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Although CoQ10 is widely recommended as a systemic antioxidant, topical application of creams containing CoQ10 may induce facial vitiligo in susceptible individuals

44 This interaction between melatonin and CAT ultimately reduces oxidative stress, helping to minimize free radical damage, which contributes to the progression of NCDs

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However, if you experience signs of allergic reactions, stop using the product

Effect of choline supplementation on rapid weight loss and biochemical variables among female taekwondo and judo athletes. Journal of human kinetics 40 (2014): 77