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Endpoint Assessment: Lipolysis: Glycerol and fatty acid release Gene expression: Lipid metabolism enzymes Body composition: Fat and lean mass Metabolic parameters: Without glucose/IGF-1 changes Mechanism Investigation: Key research questions: What is the molecular target of AOD9604

This binding activates the downstream phospholipase C-protein kinase C (PLC-PKC) signaling pathway, promoting the phosphorylation of the transcription factor cAMP response element-binding protein (CREB)

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The liver plays a central role in clearing acetaldehyde, a highly reactive and carcinogenic intermediate ( In addition, chronic alcohol intake shifts metabolism toward CYP2E1 because ADH becomes saturated at higher alcohol levels

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