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The results provide preliminary evidence for further studies to validate the neuroprotective benefits of GLP-1 RAs and SGLT-2 inhibitors and, after validation, to untangle the mechanisms of how they may help protect the brain

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In contrast, in models with GLS mutations, glutamate metabolism in tumor cells is restricted, which increases Gln concentration in the microenvironment and T-cell uptake and antitumor activity

Riva et al., 2018)