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This phenomenon is known as melting point depression

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Histopathologically, this neoplasm is usually large and asymmetric with a typical trizonal pattern featuring: i) an irregular junctional component with irregular epidermal hyperplasia and areas of prevailing single cell proliferation

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Immunofluorescent (IF) staining of K1 cells was performed and revealed a significant increase in TfR1 protein expression compared to DMSO-treated control cells (RSL3 94.7% vs

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M.MuggeA.KienkeS.BrandesR.DwengerA.et al (1995)

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