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From the abstract: Semaglutide showed robust therapeutic effects in treatment-seeking participants with obesity and alcohol use disorder and this trial supports previous preclinical and clinical findings suggesting GLP-1 receptor agonists as a potential novel treatment target for alcohol use disorder. Always a challenge with such big placebo effects in alcohol trials, and this trial provided real-human CBT to the placebo and semaglutide groups

Higher semaglutide doses linked to better heart outcomes The analysis showed that patients who attained higher semaglutide doses during the first two years of treatment also lost more weight, with each 1 mg increase in dose associated with an additional 3.15% reduction in body weight