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For a long time, scientists werent sure if adding GIP to a GLP-1 medication would help or hinder weight loss

Assuming 75% of subjects would complete the study until week 12, and 30% would be high responders, and accounting for an additional 25% dropout rate following 12 weeks, we required 38 subjects in the exenatide group and 18 in the diet/placebo group

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Although diet interventions in humans are difficult to maintain weight loss, mice respond to caloric restriction (CR) well

141 Besides, the phase IIb study of a novel granulocytemacrophage colony-stimulating factor (GM-CSF) receptor alpha monoclonal antibody, mavrilimumab, showed meaningful response by representing a novel mechanism