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In particular, pharmacokinetic/pharmacodynamic analyses of semaglutide suggest an approximately linear exposureresponse relationship for weight reduction, in contrast to the more saturable response observed for glycemic endpoints
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Retatrutide works through a different mechanism than existing GLP-1-based therapies, a factor that could broaden treatment options for patients who do not respond adequately to current medications
To view or add a comment, sign in Lillys Oral GLP-1 Orforglipron Outperforms Oral Semaglutide in T2D Eli Lilly and Company reported that its oral GLP-1 RA orforglipron delivered superior glycemic control and weight loss vs Rybelsus in the Phase 3 ACHIEVE-3 head-to-head trial in adults with type 2 diabetes published in The Lancet
