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To determine whether prevention of zinc-ATF4-ARX-induced SC--cell identity loss could improve glycemic control in SC-islets, we transplanted SC-islets into hyperglycemic mice and administered the ISR inhibitor trans-ISRIB via i.p

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[29] Combination drugs [edit] Some DPP-4 inhibitor drugs have received approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production