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Western blot assay and real-time reverse transcription polymerase chain reaction further demonstrated that the expression of odonto/osteogenic markers (ALP, RUNX2/ RUNX2 , OSX/ OSX , OCN/ OCN , COL-I/ COL-I , DSPP/ DSP , and DMP-1/ DMP-1 ) in IGF-1 treated SCAPs were significantly upregulated in Let-7c -low group