Example for someone on tirzepatide 10 mg weekly: Weeks 1-2: 7.5 mg every 7 days
The HPLC chromatogram should show one dominant peak at the expected retention time with minimal secondary peaks
wherein each substituent is independently selected from the group consisting of alkyl, alkoxy, alkoxyalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, halo, haloalkyl, sulfhydrylalkyl, alkylthioalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, carboxy, carboxyalkyl, alkyl carboxylate, alkyl alkanoate, guanidinoalkyl, R^-carbonyl, R^-carbonylalkyl, R^-acylamino, and R^-acylaminoalkyl, wherein R^ and R^ are each independently selected from the group consisting of an amino acid, an amino acid derivative, and a peptide, and wherein R^ and R^ are each independently selected from the group consisting of an amino acid, an amino acid derivative, and a peptide
SakamotoYInoueHKawakamiSMiyawakiKMiyamotoTMizutaKet al
En la prctica, esto se traduce en unos 10-12 aos de exclusividad comercial efectiva una vez aprobado el medicamento
