VDAC1 was knocked down in AGSR cells to further confirm the involvement of VDAC1 in mitophagy
Collectively, the existing preclinical and clinical data suggest that GLP-1 is involved in the pathogenesis of alcohol dependence disorders, and GLP-1R is a promising target for the development of appropriate drugs [88]
Importantly, interventional studies within clinical populations support these findings
*In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) and Zepbound (15 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)
[Google Scholar] 26.Quadros E.M., Matthews D.A., Wise I.J., Linnell J.C