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As an electrophilic chemical, ITCs might react covalently with the thiol groups of (proteins and) glutathione in plants, similar to what has been demonstrated in different in vitro systems 38,77,78 as well as in insects feeding on GSL or ITC diets 79,80

In addition, joint pathological analysis of DMM surgery p65 f/f LysM-CreER T2 mice and p65 f/f control mice with or without 8 weeks GYY4137 treatment revealed that DMM-surgery p65 f/f control mice pretreated with GYY4137 exhibit an effective amelioration in cartilage degeneration, while DMM-surgery p65 f/f LysM-CreER T2 mice treated with or without GYY4137 show no significant differences in cartilage degeneration (Fig