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Furthermore, real-world data on weight loss from this study are generally consistent with findings at around 1 year from key clinical trials and prior real-world studies of patients with overweight or obesity

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(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

It includes altered liver function, hepatic insulin resistance and lipotoxicity as key features, all of which are influenced by gut alterations that result in increased intestinal permeability [8]

Subjects came to the clinic the day before dosing and fasted overnight for 10 h before dosing (water ad libitum was allowed until 1 h before dosing)