B12 needs vary based on the cause of deficiency, symptom severity, diet, and absorption issues (such as pernicious anemia or digestive conditions)
(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)
2022 Jun 1;13:20420188221102800
(PubMed) Green R, Miller JW
Studies have shown that maintaining a normal level of cyanocobalamin in the blood leads to a reduction in homocysteine levels, thus contributing to slower aging of the brain