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These drugs block the SGLT-2 protein in the proximal convoluted tubule, thereby inducing a glucose-mediated osmotic diuresis and natriuresis, improving several metabolic measures [58]

This was mirrored by reduced MuSC senescence and increased mitochondrial respiration and membrane potential in MuSCs, paralleled by improved fitness and exercise performance

The most common gastrointestinal side effects of Wegovy include nausea (affecting 20-44% of patients), diarrhoea, constipation, vomiting, abdominal pain, and dyspepsia

And there is high likelihood that they are in fact unsafe for pregnancy since they greatly alter insulin signaling, which is a key process in pregnancy

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Zhang L., Yang M., Ren H., Hu H., Boden G., Li L., Yang G