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Lorestani, S., Bahari, A., Asadi, M., & Avval, F

Additionally, a negative correlation between complex II activity and oxidative stress measures has been reported in BD patients during depressive episodes, suggesting that mitochondrial oxidative stress related mitochondrial dysfunction may contribute to bipolar depression [50]

Traditionally, compounding is used for patients who are allergic to a medication additive or who need a liquid form instead of a pill not for patients who could take an existing name-brand medication

Mitophagy can play a protective role for cells, and the anti-apoptotic effects of Parkin have been widely reported, with early studies showing that Parkin strongly inhibits the translocation of BCL-2-associated X protein (BAX) to mitochondria, thereby preventing apoptosis [97, 98]

This can be considered a limitation and should be addressed in future studies