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Weeks 5 To 8 : 0.5 mg once weekly At this stage, appetite suppression becomes more noticeable

After treatment withdrawal (V4), this response contracted selectively, with IL-17A (p = 0.046) and IL-33 (p = 0.008) declining significantly, while other mediators showed partial but non-significant attenuation

However, increasing GH and insulin-like growth factor-1 in cancer patients raises concerns of potentially stimulating tumor growth

10.1186/s12974-019-1461-0 130 MoschettiG.KalpachidouT.AmodeoG.LattanziR.SacerdoteP.KressM.et al (2020)

a , Volcano plots showing the fold change in mitochondrial metabolite abundance (log 2 ) versus P values (-log) from K562 and HEK-293T SLC25A39 knockout cell lines expressing a vector control or SLC25A39 cDNA