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Res., 46 : 395-402

Spector TD, et al

Most of these oxygen metabolites are free radicals (H 2 O 2 is a non-radical ROS, but can easily be converted to free radicals), which have one or more unpaired electrons making them highly reactive (Reference Halliwell and Gutteridge44)

After he died in 1984, other physicians and naturopaths took up prescribing "intravenous micronutrient therapy" with unsubstantiated health claims for treating fatigue, low energy, stress, anxiety, migraine, depression, immunocompromised, promoting weight loss, and more

As exemplified above, these and other studies have shown the mechanistic role of NAD + in mitochondrial function in cellular and animal models