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GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials

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Tissue-repair and cytoprotective peptides include BPC-157, TB-500, and GHK-Cu

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Research suggests that Tirzepatide leads to greater reductions in body weight than Semaglutide, likely due to dual hormonal effects on satiety and energy metabolism (Zhou et al