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Rodents treated with GLP-1 receptor agonists demonstrated reduced joint inflammation, decreased synovial proliferation, and lower levels of inflammatory cytokines compared to untreated controls

1a, b, immunohistochemical staining and corresponding quantification of GLP-1R showed that GLP-1R of membrane is slightly but significantly downregulated in degenerative cartilage compared with normal cartilage

Avoid applying over wounds.3