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Medical summaries note GI effects are typically mild and dose-related

Their unique properties allow for the targeted delivery of anticancer drugs directly to tumor cells, minimizing damage to healthy tissues [174]

Besides the above-identified risk factors for the two different kinds of esophageal cancers, extensive research has demonstrated the role of fungal species in the development of squamous cell carcinoma in immunodeficient patients suffering from auto-immune polyendocrinopathy candidiasis ectodermal dystrophy [APECED] [54], an autosomal recessive disorder caused by mutations in the autoimmune regulator gene, which encodes the nuclear transcription protein responsible for the induction of immunological self-tolerance [55, 56]