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This happens because the drug influences brain chemicals that affect mood and thinking

In the initiation of an immune response, the antigen presenting cell displays a specific epitope complexed in an HLA-DR

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GIP exerts an insulinotropic effect, favoring pancreatic insulin release in humans [127], and recently it has been described that GIP could also stimulate glucagon release during hypoglycemia, acting as a buffer to counter the extreme changes in circulating glucose levels [128,129]

This similarity suggests that the altered energy metabolism at baseline observed in ME/CFS may compromise the ability of these patients to respond to exercise in the same way as healthy individuals