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Hierarchical clustering analyses showed an association between brain IR and specific clinical symptoms, with the highest levels of IRS-1 in L1CAM exosomes associated with suicidality, anhedonia, depressed mood and feelings of guilt

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Additionally, improved glycemic control further enhances these effects, particularly in patients with type 2 diabetes

Elevate homocysteine levels, impairing normal blood vessel function, promoting oxidative stress, and increasing risk of atherosclerosis, cardiovascular disease, insulin resistance, and Type 2 diabetes