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ATTAIN-1 (orforglipron, 72 weeks): Discontinuation due to AEs: 5.3-10.3% (orforglipron) vs 2.7% placebo Key characteristics: GI profile is broadly similar to injectable GLP-1 agonists despite oral route Nausea rates are comparable to tirzepatide The oral formulation does not appear to worsen GI tolerability relative to SC injection Safety profile described as "consistent with injectable GLP-1 medicines" Ecnoglutide# Ecnoglutide is a cAMP-biased GLP-1 receptor agonist developed by Sciwind Biosciences

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Yet, building capacity has proven to be a multi-year endeavor a fact underscored by continuing shortages and regulatory interventions ( [12] ) ( [60] )