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Q: Why are GLP-1 medications not working for me

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Do side effects return after each dose increase

Retatrutide vs tirzepatide The comparison with tirzepatide is more nuanced because tirzepatide already targets two receptors (GLP-1 and GIP)

However, markedly elevated levels without supplementation may warrant GP review to exclude underlying conditions such as haematological disorders, liver disease, or renal impairment