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Thymosin beta-4 exhibits a broader range of biological actions due to its extended sequence and additional regulatory motifs, while TB-500 provides a simplified, targeted model for studying actin-binding and local regeneration processes

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10.3389/fragi.2025.1449485 55 KordiN.SaydiA.KaramiS.Bagherzadeh-RahmaniB.MarzettiE.JungF.et al (2024)

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In a gentamicin-induced acute kidney injury experiment in rats, expression of MuRF1 and MAFbx was increased in muscle and correlated with AKI severity, whereas the expression of the other three E3 ligases (Nedd4, Trim32, and Fbxo30 / MUSA1) was irrelevant