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People taking warfarin should have their INR monitored more closely, as orlistat may affect anticoagulant control

NIA P01AG021654, P30AG038072, R37AG18381 and the Paul Glenn Foundation for Medical Research to N.B

doi: 10.1210/jcem-41-2-260 120 ChangAMJakobsenGSturisJSmithMJBloemCJAnBet al

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These two events are mechanistically separable: extracellular domain binding affinity does not predict transmembrane domain activation efficiency, and mutations in the extracellular domain can selectively abolish -arrestin recruitment while preserving cAMP production