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Sphingolipids such as ceramide and sphingosine are important in apoptotic machinery of programmed cell death, while S1P is involved in cell proliferation, migration, angiogenesis, inflammatory responses, and lymphocyte trafficking

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Similarly, sex-specific differences in neuroinflammatory and neuroregenerative responses are increasingly recognized, reinforcing the need for sex-balanced study designs [576]

A total of 250 bioactive compounds in BP have been known so far (4447)