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The results of their research demonstrated significant inhibitory effect of GSH-MEE and GSH-MIPE, but not GSH, on intracellular tyrosinase activity and melanin production

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

The infection by COVID-19 downregulates ACE2