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The same thio-ester is accepted by the co-activator p300 and its paralogue CREB-binding protein (CBP), which write H4K12la at active promoters and enhancers in diverse cancers and stem cells, and by the (MOZ-Ybf2/Sas3-Sas2-Tip60) MYST enzyme histone-acetyltransferase-bound-to-ORC1 (HBO1), whose preference for H3K9la stimulates invasion programmes in solid tumors [42, 43]
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