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Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

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In analyses excluding individuals with no BMI information and using multiple imputation for BMI missing values, respective HRs were 0.89 (95% CI 0.26, 3.14) and 1.29 (95% CI 0.42, 3.92) (Table 2)

CD206 + monocyte-derived DCs from membrane-associated ring-CH-type finger 1 knockout mice exhibit overexpression of MHC-II, reduced expression of IRF4 and CCR7, and impaired migration from the skin to the sdLN