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These studies suggest that deficiencies in GH and IGF-I contribute to a functional decline in senescent rats, whereas augmentation of GH or IGF-I improves cognitive function, increases glucose utilization throughout the brain, increases cortical vascularity, and ameliorates age-related decline in hippocampal neurogenesis

Moreover, RNA sequencing analysis has demonstrated that SLC7A11 expression levels were significantly increased in mouse models of breast cancer with brain metastases (63,64)

The improved gene expression profile in visceral WAT in NDI1-expressing mice after HFD feeding prompted us to further examine the role of CI in visceral adipocytes