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Clinical studies most often report mild side effects, including nausea, vomiting, diarrhea, heartburn, gas, headache, and general digestive discomfort.27 A 2021 safety review of high-dose NAC in chronic respiratory diseases found that oral doses between 600mg and 3,000mg daily were generally well tolerated, with gastrointestinal symptoms reported but not consistently more often than placebo.35 That doesnt mean NAC is risk-free
Prescribe additional medications in the first week of Wellbutrin treatment to manage side effects such as restlessness and agitation if needed
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In clinical trials and functional medicine protocols, the dosing of NAC typically ranges from 500 mg to 1,200 mg per day, often divided into two doses to maintain consistent plasma levels
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