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In diabetic patients and animal models, phosphorylation of the Drp1-Ser637 site in podocytes and endothelial cells in a high-glucose environment drives the translocation of Drp1 to mitochondria, which in turn promotes mitochondrial fission (Wang W

This is for good reason

They deliver instructions to your cells telling them what to do, like 'make more collagen' or 'heal this wound.' Think of them like text messages your body sends to itself

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Given the number of drugs on the shortage list, one would think that there are standard metrics for making such conclusions