Early recognition and appropriate management of side effects can often allow continued treatment with dose adjustments or supportive measures rather than requiring discontinuation of therapy
Stimulant-based drugs reduce appetite but may raise heart rate and blood pressure, and can cause trouble sleeping or nervousness
Thus, the Cochrane review may have been somewhat limited by not just the number of women studied but the duration of clinical trials
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119 Research indicates that factors such as age, diet, alcohol consumption, fructose-rich intake, pharmacologic interventions and diseases, such as obesity, insulin resistance, Down syndrome, and kidney disease, contribute to the development of hyperuricemia 120,121,122,123,124 (Fig