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Common symptoms associated with leaky gut syndrome include: Headaches Brain fog Food allergies or sensitivities Diarrhea or constipation Hormonal imbalance Anxiety, depression Acne, eczema, rosacea Joint pain Fatigue Conditions Associated with Leaky Gut Autoimmune conditions Rheumatoid arthritis, Multiple sclerosis (MS), Systemic lupus erythematosus, Diabetes Autism Cancer glioma, hepatocellular carcinoma Chronic fatigue syndrome (ME/CFS) Fibromyalgia Inflammatory bowel disease Crohns disease, ulcerative colitis Irritable bowel syndrome (IBS) Testing for Leaky Gut Zonulin is considered the master regulator of intracellular junctions