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By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

The most common are nausea, vomiting, diarrhea, and constipation, affecting between 20 and 40 percent of patients in the STEP and SURMOUNT trials

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In cultured fibroblasts, exposure to the compound at concentrations as low as 10 nM has produced measurable increases in collagen synthesis within 48 hours

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