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Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association

NADPH contributes to recycling in oxidized antioxidant systems involving glutathione, thioredoxins, glutaredoxins, and peroxiredoxins and maintains another reactive oxygen species (ROS)-detoxifying enzyme, catalase, in its active form, suggesting that the homeostatic level of G6PD-derived NADPH determines the rate of oxidative damage [8]

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Their research identified four primary biological processes in POP: the epithelialmesenchymal transition, immune response activation, ECM modulation, and fibroblast survival and apoptosis