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The mechanism by which semaglutide may induce these complications is thought to be related to its effects on bile acid metabolism

Suppressing appetite, leading to reduced calorie intake and weight loss

The pathophysiology is thought to involve increased sensitivity to cholecystokinin (CCK), leading to excessive gallbladder contractility

As well as producing red blood cells, vitamin B12 transports oxygen throughout the body

Several randomized controlled trials have shown lifestyle interventions reduce body weight, improve hepatic triglyceride content and improve MASLD activity score in patients suffering from MASLD (249254)