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2 In 2018, MDD ranked third in terms of disease burden according to the WHO, and it is predicted to rank first by 2030

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In research, GH secretagogues are usually grouped into two major categories: GHRH analogs, which activate the growth hormonereleasing hormone receptor Ghrelin/GHSR agonists, which activate the growth hormone secretagogue receptor Both pathways can increase GH-axis activity, but they do so through different upstream signals

"They have a different impact on the brain