Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB
The results showed that Akkermansia muciniphila was significantly more abundant (p = 0.02, fold change = 3.3) and Faecalibacterium prausnitzii significantly less abundant in MCS patients than in HC (p = 0.03, fold change = 0.53). They also found that xylene and dioxin degradation pathways were upregulated.[ref] Interestingly, Akkermansia muciniphila is currently being promoted as a probiotic
Abbreviations Akt, PKB: Protein kinase B AP-1: Activator protein 1 IP3R: Inositol 1,4,5-trisphosphate receptor Mdm2: Mouse double minute 2 NFAT C 4: Nuclear factor of activated T cell 4 PDK1: Phosphoinositide-dependent kinase-1 PH domain: Pleckstrin homology domain RH domain: Regulator of G protein signaling homology domain SDS-PAGE: Sodium dodecyl sulfate polyacrylamide gel electrophoresis USP33: Ubiquitin carboxyl-terminal hydrolase 33 References Hausdorff WP, Caron MG, Lefkowitz RJ
J Child Neurol 2006;21(2):170-172
The indirect may be via its anabolic mediator IGF-1 (insulin-like growth factor-1), which is produced in other tissue cells when they are presented with hGH
