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Therefore, GLP-1 RAs with CV benefit may hold future therapeutic promise in people with T2D

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Dose increases usually occur when: You tolerate the current dose well Digestive symptoms are minimal Appetite suppression begins to level out You are progressing comfortably Your titration may slow down if you experience: Persistent nausea Vomiting Dizziness or fatigue Difficulty maintaining adequate nutrition Rapid or uncomfortable early weight loss A slower titration is completely normal and often improves long-term success

Kelly E, Greene CM, Carroll TP, McElvaney NG, O'Neill SJ

2018;136(Pt B):343349