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They also help regulate immune responses by affecting other immune cells activity [84]

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For a 75 kg adult patient, a loading dose of 300 mg of CST base activity (equivalent to 9 million international units, IU) is recommended, followed by maintenance dosing of 150 mg every 12 h

While folic acid is the key preventive measure for neural tube defects, ensuring adequate B12 status is also important for overall maternal and foetal health

Acne (especially jawline, chin, lower-face) Spironolactone went from off-label option to evidence-based first-line for adult female acne in 2023 with the SAFA trial a UK multicenter, double-blind, placebo-controlled RCT of 410 women published in The BMJ and Health Technology Assessment