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Conjugated primary bile acids, including cholic acid (CA) and chenodeoxycholic acid (CDCA), undergo deconjugation catalyzed by bile salt hydrolases (BSHs) expressed by probiotic bacteria, such as Lactobacillaceae and Bifidobacterium spp .leading to the production of free bile acids 144

The average HbA1c reduction may have been attenuated by floor effect, as a high proportion of participants approached near-normal glycaemic levels

Semaglutide is in the GLP-1 receptor agonist class of medications

NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)

Cancer Cell 19 , 416428 (2011)