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Metformin, involved in the metabolic reprogramming of tumor cells, can downregulate glycolysis and inhibit cancer growth, but its therapeutic efficacy is limited in hypoxic microenvironments ( 4.4 Autophagy-mediated ferroptosis Plant polysaccharides can enhance ferroptosis against cancer by activating autophagy pathways, causing ferritin degradation and Fe 2+ accumulation
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference
10.1016/j.beem.2011.06.007 89
This refined understanding underscores the necessity of cell-type-targeted therapeutic strategies that either protect vulnerable cells or modulate the response of resistant cells in cardiovascular diseases
doi: 10.1016/S0021-9258(18)99661-4
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