The resulting pharmacokinetic profile changes the timing and amplitude of GH and downstream IGFI signals, which can impact reproductive hormone systems associated with fertility
Research has also found that SAT1 induction is associated with the expression of arachidonate 15-lipoxygenase (ALOX15), which is essential in p53-mediated ferroptosis (Chu et al., 2019)
In some cases, adjusting the dose of oral progesterone may be necessary, but this should only be done in consultation with a healthcare provider
These included: Nausea (the most frequently reported GI symptom) Vomiting Diarrhoea Constipation Decreased appetite was also commonly reported, though this is better understood as a pharmacodynamic effect of the drug rather than a GI adverse event in the conventional sense
All other food groups are excluded, including vegetables, fruits, grains, legumes, nuts, and seeds