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COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

Due to sperms abundance of membrane polyunsaturated fatty acids (PUFAs) and their own innate capacity to generate reactive oxygen species (ROS) (via abnormally shaped sperm morphology), human sperm are highly susceptible to oxidative stress (inflammation)

The female-specific two-step MR analysis corroborated the direction and nature of our primary findings, despite reduced statistical power due to smaller sample sizes

J Biol Chem 265:1291612926 Richards EM, Rosenthal RE, Kristian T, Fiskum G (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity

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