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Two years after the initiation of combination therapy with dapagliflozin and semaglutide, the patient continues with an excellent glycemic control (HbA1c 6.4%- 46 mmol/mol)

Analysis of single-cell RNA sequencing Single-cell RNA sequencing (scRNA-seq) data (HRA000425) were downloaded from Genome Sequence Archive (SRA)-Human databases in China National Center for Bioinformation 16 , converted into FASTQ format using fasterq-dump software (sratoolkit 3.0.2, NCBI, NIH, Bethesda, MD, USA), converted into a matrix data file using Cell Ranger software version 3.0.2 (10xGenomics, Pleasanton, CA, USA), converted into Seurat objects using Seurat 5.0.1 software (Satija lab, Lower Manhattan, New York, NY, USA), and plotted for t -distributed stochastic neighbor embedding ( t -SNE) visualization

Manufacturer Strategy: IP and Market Access Alignment For pharmaceutical and biotech companies, the PBM landscape requires treating formulary access as an intellectual property-equivalent asset that depreciates with contract renegotiation cycles