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Antibodies to the S proteins of SARS-CoV and SARS-CoV-2and, to a much lesser extent, MERS-CoVcan cross-react, and both high-potency neutralizing antibodies that also mediate antibody-dependent cytotoxicity and antibody-dependent cellular phagocytosis 69 , as well as non-neutralizing antibodies, can be elicited against conserved S epitopes 70,71

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Specific muscles of the rats were dosed with a measured vial of the compound

Study-specific OR estimates were pooled using either a fixed-effects model or a random-effects model in case a significant heterogeneity exists